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1

Foldamer Tertiary Structure through Sequence-Guided Protein Backbone Alteration

George, Kelly L., Horne, W. Seth

Journal:

Accounts of Chemical Research

Year:

2018

Language:

english

File:

PDF, 4.37 MB

english, 2018

2

Foldamers with Heterogeneous Backbones

Horne, W. Seth, Gellman, Samuel H.

Journal:

Accounts of Chemical Research

Year:

2008

Language:

english

File:

PDF, 1.74 MB

english, 2008

3

Tuning Assembly Size in Peptide-Based Supramolecular Polymers by Modulation of Subunit Association Affinity

Oshaben, Kaylyn M., Horne, W. Seth

Journal:

Biomacromolecules

Year:

2014

Language:

english

File:

PDF, 4.10 MB

english, 2014

4

Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure

Reinert, Zachary E., Horne, W. Seth

Journal:

Organic & Biomolecular Chemistry

Year:

2014

Language:

english

File:

PDF, 1.67 MB

english, 2014

5

Sequence-Based Design of α/β-Peptide Foldamers That Mimic BH3 Domains

W. Seth Horne, Melissa D. Boersma, Matthew A. Windsor, Samuel H. Gellman

Journal:

Angewandte Chemie

Year:

2008

Language:

english

File:

PDF, 440 KB

english, 2008

6

Conformationally Homogeneous Heterocyclic Pseudotetrapeptides as Three-Dimensional Scaffolds for Rational Drug Design: Receptor-Selective Somatostatin Analogues

John M. Beierle, W. Seth Horne, Jan H. van Maarseveen, Beatrice Waser, Jean Claude Reubi, M. Reza Ghadiri

Journal:

Angewandte Chemie

Year:

2009

Language:

english

File:

PDF, 833 KB

english, 2009

7

Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole-Modified Cyclic Tetrapeptides

W. Seth Horne, Christian A. Olsen, John M. Beierle, Ana Montero, M. Reza Ghadiri

Journal:

Angewandte Chemie

Year:

2009

Language:

english

File:

PDF, 828 KB

english, 2009

8

Sequence-Based Design of α/β-Peptide Foldamers That Mimic BH3 Domains

W. Seth Horne, Melissa D. Boersma, Matthew A. Windsor, Samuel H. Gellman

Journal:

Angewandte Chemie International Edition

Year:

2008

Language:

english

File:

PDF, 440 KB

english, 2008

9

Conformationally Homogeneous Heterocyclic Pseudotetrapeptides as Three-Dimensional Scaffolds for Rational Drug Design: Receptor-Selective Somatostatin Analogues

John M. Beierle, W. Seth Horne, Jan H. van Maarseveen, Beatrice Waser, Jean Claude Reubi, M. Reza Ghadiri

Journal:

Angewandte Chemie International Edition

Year:

2009

Language:

english

File:

PDF, 833 KB

english, 2009

10

Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole-Modified Cyclic Tetrapeptides

W. Seth Horne, Christian A. Olsen, John M. Beierle, Ana Montero, M. Reza Ghadiri

Journal:

Angewandte Chemie International Edition

Year:

2009

Language:

english

File:

PDF, 828 KB

english, 2009

11

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

Dr. Erinna F. Lee, Assoc. Prof. Brian J. Smith, Dr. W. Seth Horne, Kelsey N. Mayer, Marco Evangelista, Prof. Peter M. Colman, Prof. Samuel H. Gellman, Dr. W. Douglas Fairlie

Journal:

Year:

2011

Language:

english

File:

PDF, 783 KB

english, 2011

12

Cover Picture: Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design (ChemBioChem 13/2011)

Dr. Erinna F. Lee, Assoc. Prof. Brian J. Smith, Dr. W. Seth Horne, Kelsey N. Mayer, Marco Evangelista, Prof. Peter M. Colman, Prof. Samuel H. Gellman, Dr. W. Douglas Fairlie

Journal:

Year:

2011

Language:

english

File:

PDF, 978 KB

english, 2011

13

Modulating Charge Transfer through Cyclic D,L-α-Peptide Self-Assembly

W. Seth Horne, Nurit Ashkenasy, M. Reza Ghadiri

Journal:

Chemistry - A European Journal

Year:

2005

Language:

english

File:

PDF, 205 KB

english, 2005

14

Efficient Route to C2 Symmetric Heterocyclic Backbone Modified Cyclic Peptides.

Jan H. van Maarseveen, W. Seth Horne, M. Reza Ghadiri

Journal:

Year:

2006

File:

PDF, 8 KB

2006

15

Antiviral cyclic d,l-α-peptides: Targeting a general biochemical pathway in virus infections

W. Seth Horne, Christopher M. Wiethoff, Chunli Cui, Keith M. Wilcoxen, Manuel Amorin, M. Reza Ghadiri, Glen R. Nemerow

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 332 KB

english, 2005

16

Design of Self-Assembling Peptide Nanotubes with Delocalized Electronic States

Nurit Ashkenasy, W. Seth Horne, M. Reza Ghadiri

Journal:

Year:

2006

Language:

english

File:

PDF, 401 KB

english, 2006

17

Cover Picture: Design of Self-Assembling Peptide Nanotubes with Delocalized Electronic States (Small 1/2006)

Nurit Ashkenasy, W. Seth Horne, M. Reza Ghadiri

Journal:

Year:

2006

File:

PDF, 36 KB

2006

18

Enhancement of α-Helix Mimicry by an α/β-Peptide Foldamer via Incorporation of a Dense Ionic Side-Chain Array

Mortenson, David E., Yun, Hyun Gi, Horne, W. Seth, Ketas, Thomas J., Lu, Min, Moore, John P., Gellman, Samuel H., Johnson, Lisa M.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 317 KB

english, 2012

19

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

Boersma, Melissa D., Haase, Holly S., Peterson-Kaufman, Kimberly J., Lee, Erinna F., Clarke, Oliver B., Colman, Peter M., Smith, Brian J., Horne, W. Seth, Fairlie, W. Douglas, Gellman, Samuel H.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 4.45 MB

english, 2012

20

A PEG-Based Oligomer as a Backbone Replacement for Surface-Exposed Loops in a Protein Tertiary Structure

Zachary E. Reinert, Dr. Eli D. Musselman, Prof. Adrian H. Elcock, Prof. W. Seth Horne

Journal:

Year:

2012

Language:

english

File:

PDF, 996 KB

english, 2012

21

Waiting for the National Cholesterol Education Program Adult Treatment Panel IV Guidelines, and in the Meantime, Some Challenges and Recommendations

Seth S. Martin, Thomas S. Metkus, Aaron Horne, Michael J. Blaha, Rani Hasan, Catherine Y. Campbell, Omair Yousuf, Parag Joshi, Sanjay Kaul, Michael Miller, Erin D. Michos, Steven R. Jones, Ty J. Gluck

Journal:

The American Journal of Cardiology

Year:

2012

Language:

english

File:

PDF, 653 KB

english, 2012

22

Heterocyclic Peptide Backbone Modifications in an α-Helical Coiled Coil

Horne, W. Seth, Yadav, Maneesh K., Stout, C. David, Ghadiri, M. Reza

Journal:

Journal of the American Chemical Society

Year:

2004

Language:

english

File:

PDF, 178 KB

english, 2004

23

Hairpin Folding Behavior of Mixed α/β-Peptides in Aqueous Solution

Lengyel, George A., Frank, Rebecca C., Horne, W. Seth

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 869 KB

english, 2011

24

Psoriasis treatment patterns: Results of a cross-sectional survey of dermatologists

Vaishali Patel, Elizabeth J. Horn, Steve J. Lobosco, Kathleen M. Fox, Seth R. Stevens, Mark Lebwohl

Journal:

Journal of the American Academy of Dermatology

Year:

2008

Language:

english

File:

PDF, 327 KB

english, 2008

25

The Native GCN4 Leucine-Zipper Domain Does Not Uniquely Specify a Dimeric Oligomerization State

Oshaben, Kaylyn M., Salari, Reza, McCaslin, Darrell R., Chong, Lillian T., Horne, W. Seth

Journal:

Year:

2012

Language:

english

File:

PDF, 1.92 MB

english, 2012

26

β-Hairpin-Mediated Nucleation of Polyglutamine Amyloid Formation

Kar, Karunakar, Hoop, Cody L., Drombosky, Kenneth W., Baker, Matthew A., Kodali, Ravindra, Arduini, Irene, van der Wel, Patrick C.A., Horne, W. Seth, Wetzel, Ronald

Journal:

Journal of Molecular Biology

Year:

2013

Language:

english

File:

PDF, 2.13 MB

english, 2013

27

Practical Synthesis of Enantiomerically Pure β 2 -Amino Acids via Proline-Catalyzed Diastereoselective Aminomethylation of Aldehydes

Chi, Yonggui, English, Emily P., Pomerantz, William C., Horne, W. Seth, Joyce, Leo A., Alexander, Lane R., Fleming, William S., Hopkins, Elizabeth A., Gellman, Samuel H.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 87 KB

english, 2007

28

A Heterocyclic Peptide Nanotube

Horne, W. Seth, Stout, C. David, Ghadiri, M. Reza

Journal:

Journal of the American Chemical Society

Year:

2003

Language:

english

File:

PDF, 200 KB

english, 2003

29

Efficient Route to C 2 Symmetric Heterocyclic Backbone Modified Cyclic Peptides

van Maarseveen, Jan H., Horne, W. Seth, Ghadiri, M. Reza

Journal:

Organic Letters

Year:

2005

Language:

english

File:

PDF, 86 KB

english, 2005

30

Protein-like Tertiary Folding Behavior from Heterogeneous Backbones

Reinert, Zachary E., Lengyel, George A., Horne, W. Seth

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 1.62 MB

english, 2013

31

Total Synthesis and Biological Evaluation of Pederin, Psymberin, and Highly Potent Analogs

Wan, Shuangyi, Wu, Fanghui, Rech, Jason C., Green, Michael E., Balachandran, Raghavan, Horne, W. Seth, Day, Billy W., Floreancig, Paul E.

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 4.67 MB

english, 2011

32

THE UTILITY OF APOLIPOPROTEIN A1, REMNANT LIPOPROTEINS, AND THE APOLIPOPROTEIN A1 REMNANT RATIO TO THE INCIDENCE OF CORONARY HEART DISEASE IN A PRIMARY PREVENTION COHORT OF AFRICAN AMERICANS OVERALL AND BY SEX: THE JACKSON HEART STUDY

May, Heidi Thomas, Nelson, John, Lirette, Seth, Kulkarni, Krishnaji, Anderson, Jeffrey, Griswold, Michael, Horne, Benjamin, Correa, Adolfo, Muhlestein, J.

Journal:

Journal of the American College of Cardiology

Year:

2014

Language:

english

File:

PDF, 825 KB

english, 2014

33

Structural Consequences of β-Amino Acid Preorganization in a Self-Assembling α/β-Peptide: Fundamental Studies of Foldameric Helix Bundles

Price, Joshua L., Horne, W. Seth, Gellman, Samuel H.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 526 KB

english, 2010

34

High-Resolution Structure of a Protein Spin-Label in a Solvent-Exposed β-Sheet and Comparison with DEER Spectroscopy

Cunningham, Timothy F., McGoff, Marshall S., Sengupta, Ishita, Jaroniec, Christopher P., Horne, W. Seth, Saxena, Sunil

Journal:

Year:

2012

Language:

english

File:

PDF, 2.67 MB

english, 2012

35

An α/β-Peptide Helix Bundle with a Pure β 3 -Amino Acid Core and a Distinctive Quaternary Structure

Giuliano, Michael W., Horne, W. Seth, Gellman, Samuel H.

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 1.87 MB

english, 2009

36

Origins of Structural Flexibility in Protein-Based Supramolecular Polymers Revealed by DEER Spectroscopy

Tavenor, Nathan A., Silva, K. Ishara, Saxena, Sunil, Horne, W. Seth

Journal:

Journal of Physical Chemistry B

Year:

2014

Language:

english

File:

PDF, 3.98 MB

english, 2014

37

Helix Bundle Quaternary Structure from α/β-Peptide Foldamers

Horne, W. Seth, Price, Joshua L., Keck, James L., Gellman, Samuel H.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 361 KB

english, 2007

38

Broad Distribution of Energetically Important Contacts across an Extended Protein Interface

Johnson, Lisa M., Horne, W. Seth, Gellman, Samuel H.

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 3.72 MB

english, 2011

39

Discrete Heterogeneous Quaternary Structure Formed by α/β-Peptide Foldamers and α-Peptides

Price, Joshua L., Horne, W. Seth, Gellman, Samuel H.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 165 KB

english, 2007

40

Introduction of Cyclically Constrained γ-Residues Stabilizes an α-Peptide Hairpin in Aqueous Solution

Lengyel, George A., Eddinger, Geoffrey A., Horne, W. Seth

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 1.17 MB

english, 2013

41

Design Strategies for the Sequence-Based Mimicry of Side-Chain Display in Protein β-Sheets by α/β-Peptides

Lengyel, George A., Horne, W. Seth

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 3.22 MB

english, 2012

42

Promoting peptide α-helix formation with dynamic covalent oxime side-chain cross-links

Haney, Conor M., Loch, Matthew T., Horne, W. Seth

Journal:

Chemical Communications

Year:

2011

Language:

english

File:

PDF, 2.49 MB

english, 2011

43

Stable isotopes evaluate exploitation of anthropogenic foods by the endangered San Joaquin kit fox (Vulpes macrotis mutica)

Newsome, Seth D., Ralls, Katherine, Job, Christine Van Horn, Fogel, Marilyn L., Cypher, Brian L.

Journal:

Journal of Mammalogy

Year:

2010

Language:

english

File:

PDF, 305 KB

english, 2010

44

A modular synthetic platform for the construction of protein-based supramolecular polymers via coiled-coil self-assembly

Staples, J. Kenneth, Oshaben, Kaylyn M., Horne, W. Seth

Journal:

Chemical Science

Year:

2012

Language:

english

File:

PDF, 594 KB

english, 2012

45

Folding thermodynamics of protein-like oligomers with heterogeneous backbones

Reinert, Zachary E., Horne, W. Seth

Journal:

Chemical Science

Year:

2014

Language:

english

File:

PDF, 546 KB

english, 2014

46

Potassium Intake and Risk of Stroke in Women With Hypertension and Nonhypertension in the Women's Health Initiative

Seth, A., Mossavar-Rahmani, Y., Kamensky, V., Silver, B., Lakshminarayan, K., Prentice, R., Van Horn, L., Wassertheil-Smoller, S.

Journal:

Year:

2014

Language:

english

File:

PDF, 734 KB

english, 2014

47

Dynamic covalent side-chain cross-links via intermolecular oxime or hydrazone formation from bifunctional peptides and simple organic linkers

Haney, Conor M., Horne, W. Seth

Journal:

Journal of Peptide Science

Year:

2014

Language:

english

File:

PDF, 830 KB

english, 2014

48

Comparison of backbone modification in protein β-sheets by α→γ residue replacement and α-residue methylation

Lengyel, George A., Reinert, Zachary E., Griffith, Brian D., Horne, W. Seth

Journal:

Organic & Biomolecular Chemistry

Year:

2014

Language:

english

File:

PDF, 1.96 MB

english, 2014

49

Peptide and peptoid foldamers in medicinal chemistry

Journal:

Expert Opinion on Drug Discovery

Year:

2011

Language:

english

File:

PDF, 730 KB

english, 2011

50

Oxime Side-Chain Cross-Links in an α-Helical Coiled-Coil Protein: Structure, Thermodynamics, and Folding-Templated Synthesis of Bicyclic Species

Haney, Conor M., Horne, W. Seth

Journal:

Chemistry - A European Journal

Year:

2013

Language:

english

File:

PDF, 917 KB

english, 2013

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